At test locations, before the game had an official title, the cabinet marquee read "Hide From and Shoot the Chinese Mafia".

[8] In The Keisatsukan: Shinjuku Ni Juu Yo Ji, the players begin on the streets of Kabuki-cho of Shinjuku, taking part in a raid on a nightclub owned by the Gokudo-kai; the officers, accompanied by shielded riot squad members and surrounded by civilians, can take different routes through the club as their shooting skill dictates.

Once the players exit the club, they will be alerted that the suspects have scattered all over Japan to escape arrest, and arrest warrants have been issued for the 6 most wanted criminals in Shinjuku: Shigenobu Matsuyama (松山 重信, Matsuyama Shigenobu), international weapon smuggler Richard Hansen, Keisuke Matsuoka (松岡 圭介, Matsuoka Keisuke), Bai Ei Lee (李培栄), Noriko Nagata (長田 典子, Nagata Noriko), and Katsuji Haraguchi (原口 勝治, Haraguchi Katsuji).

In The Keisatsukan: Shinjuku Ni Juu Yo Ji, a newspaper headline flashes on the screen whenever a civilian is shot, because he or she can actually be killed.

In Police 911/Police 24/7, the gameplay missions are reversed: the raid on the nightclub takes place in Los Angeles' Little Tokyo, followed by a "boss" fight with Richard Hansen at the crowded intersection with textures and buildings being digital replicas of the actual buildings around Los Angeles' 1st St. and San Pedro St.

The game takes place exclusively in Japan and players can choose 6 cities—Osaka, Hakata, Shinjuku, Kobe, Nagoya, and Sapporo.

The rest of the game takes place in normal stages before the player has to return to Osaka to arrest the remaining criminals.

In the overseas version, the police woman and the detective are male and female American Interpol Operatives holding 8-round Glocks.

Criminal activity has increased by order of the infamous Gokudo-kai yakuza group, who has entered a partnership with a Hong Kong Triad called Ryuuto (龍頭) (Dragonhead in English).

Players start the investigation inside an office building where a collaboration deal is taking place between the Gokudo-kai and the Dragonheads.