From 1279 when King Charles came down into Italy and campaigned throughout the South, Pollutri became part of the Kingdom of Naples, from which depended politically until 1860, when Garibaldi drove out the Bourbons.

On 28 August 1292, The University, which was the center of civil life, elected as supreme judges of Pollutri: James Gizio, Di Stefano De Lorenzo and Roberto Fura.

In 1576 Alessandro Muzio saw an apparition of the Virgin Mary, which was reported by his son Joseph, dean of Pollutri in the book one of those baptized, and those confirmed dead, preserved in the parish, and summarized by Gabriele D'Annunzio in "The Triumph of Death" (edition of Treves, Milan, pages 297-1903).

The county included twelve other regions: Pennaluce, Cupello, Scerni, Casalbordino, Guildford, Villalfonsina, Lentella, Furci, Gissi, Casalanguida, Smooth Colledimezzo.

Not long thereafter, the Earl of Penne, Francesco D'Aquino, with fresh, well-trained troops, regained Monteodorisio County, and therefore also the territory of Pollutri, which he at once gave to his niece Antonella, wife of Junichi d'Avalos, brave general of Spanish origin.