Saint Euphrosyne Polotsk State University (Belarusian: Полацкі дзяржаўны ўніверсітэт імя Ефрасінні Полацкай; Russian: Полоцкий государственный университет имени Евфросинии Полоцкой) is a Belarusian public university based in Novopolotsk and Polotsk.

The official seal of the university depicts the buildings that originally housed the Jesuit College in Polotsk.

[6] On January 12, 1812, the college was reclassified into Polotsk Jesuit Academy by an ukase of the Emperor of Russia, Alexander I.

On January 1, 1974, it became Novopolotsk Polytechnical Institute named after Leninist Young Communist League of Belarus.

The lyrics of the Polotsk State University anthem were written by Belarusian poet Hienadz Buraukin.