Polychromophilus follows a fairly typical Haemospororidian lifecycle, with gametocytes and gametes restricted to the bloodstream of the host and meronts infecting organs – most notably the lungs and the liver.

In 1906, Schingareff managed to observe and describe merozoites within macrophages of Myotis daubentoni and Miniopterus schreibersi and suspected that nycteribiid flies acted as insect vectors.

Upon maturation, the oocyst bursts releasing the sporozoites into the insect vector, where they migrate toward the salivary gland ready to continue their cycle.

[4] Merogony of the parasite, although less well understood, has been observed to occur in a variety of organs and cell types of the primary bat host.

Large bodies have been discovered in organs including the spleen and lungs, while small meronts have been found to develop within the Kupffer cells of the liver.

The presence of the parasite has since been discovered in numerous locations worldwide, including Israel, Australia, the Congo, Ethiopia, Brazil, and North America.

Multiple intracellular organelles are visible within the gametocytes, including mitochondria with tubular cristae, a Golgi apparatus, micronemes, primary lysosomes, and a microtubule organising centre comprising two centrioles.

Macrogametocytes, on the other hand, stain blue-purple due to a higher number of ribosomes within the cytoplasm and contain a small distinct nucleus with a clearly visible nucleolus.