[2] The drama is set in ancient Armenia (in a city, Melitene, which is in present-day Turkey) during a time when Christians were persecuted there under the Roman Empire.
Polyeucte, an Armenian nobleman, converts to Christianity to the great despair of his wife, Pauline, and of his father-in-law, Felix.
Polyeucte is one of the last 17th-century French dramas with a religious subject—Corneille did also write Théodore in 1645 and Racine wrote Esther (1689) and Athalie (1691), but these were not meant for public performance.
The opera was not a success and is rarely performed except for a number of arias including "Source délicieuse" and the barcarolle "Nymphes attentives".
Other works based on the play include a ballet by Marc-Antoine Charpentier (1679), the opera Poliuto (1838) by Donizetti (adapted into French by Scribe as Les martyrs), an overture by Paul Dukas (1891) and a composition by Edgar Tinel.