Polymeridium multiforme is a species of corticolous (bark-dwelling) lichen in the family Trypetheliaceae.

[1] It is found in the Neotropics, with specimens recorded from Brazil, Guyana, and Venezuela.

The type specimen was collected in Guyana, at the base of Makarapan Mountain [ceb], on the bark of a Myrsinaceae tree.

[2] The ascomata of P. multiforme are 0.2–0.3 mm in diameter, with a spherical centrum that is erumpent and solitary.

The ostiole is apical, and the hamathecium features filaments that profusely anastomose.