[2] The Polytechnic University of Bari was established with Italian law “Legge n. 245” of 7 August 1990.

Following the reform initiated with the Italian law Legge n. 240 of 2010 and successive modifications, the Polytechnic University of Bari has organized its structure prominently based on departments with an aggregation into five big departments, most of which divided into branches: Most of the structures, classrooms, halls and departments are located inside the campus "Ernesto Quagliariello" in Bari.

It is shared with the University of Bari (only for scientific subjects), and it is located close to via Orabona.

In Bari's Japigia quarter are located most of the offices and laboratories of the Departments of Mechanical Engineering, Mathematics and Management.

The Polytechnic University of Bari is also present in other two separate branches, in Foggia and Taranto (where "Centro Interdipartimentale Magna Grecia" is located).