Her father was the Doge Pietro Fregoso (died 1404), and her mother was either Theodora Spinola or Benedetta Doria.

Monaco itself was occupied by the Duchy of Milan in 1436, but freed, upon which Jean placed Pomellina there to manage the fortress in his absence.

[1] During this period, Jean I was held prisoner by Filippo Maria Visconti, who threatened to kill him if Monégasque power was not turned over to him.

In his will, he stated that he was to be succeeded by his daughter Claudine who (to adjust to the will of his father that a female ruler was not to result in a change in dynasty), was to marry her cousin Lamberto, Lord of Monaco.

[1] In July 1457, Catalan died when Claudine was at the age of six, and Pomellina Fregoso duly became regent of Monaco in accordance with the written will of her son.

[1] In March 1458, the plot was staged, but Lambert managed to escape: with the support of the population of Menton and Roquebrune, he deposed Pomellina's regency government, confined her to her house in Menton, and had himself declared sovereign Lord as well as the regent and possessor of the rights of Claudine.