Ponatshego Honorius Kefaeng Kedikilwe (born 7 July 1938) is a Motswana politician who was Vice-President of Botswana from 2012 to 2014.

A member of the ruling Botswana Democratic Party (BDP), he has also served as Minister of Minerals, Energy, and Water Resources since 2007.

[5][6] Khama had been backed for the post by Former President Festus Mogae,[7] and the outcome was viewed as crucial, paving the way for Khama to eventually succeed Mogae as president during that time[5] Kedikilwe was appointed as Minister of Minerals, Energy, and Water Resources in January 2007.

The government said that Kedikilwe would retain his portfolio as Minister of Minerals, Energy, and Water Resources.

Following the 2014 general election, Khama instead nominated Mokgweetsi Masisi as vice-president on 12 November 2014.