In the High Middle Ages, a chapel devoted to St Mary was added to the structure.

Ambrussum contains three archaeological sites of international importance: the Colline de Devès which was first occupied in 2300 BC and settled as an oppidum between 300 BC and 100 AD; the Roman staging post on the Via Domitia which had hotels, a baths and industrial buildings; and the Pont Ambroix.

The bridge was sketched by Anne Rulman in 1620 and the drawing shows only four arches.

The Vidourlades are violent floods on the Vidourle, in which the water flow increases from a minimum of 3 m3/s to over 3000 m3/s.

The site was abandoned when transit patterns changed; the Via Domitia became less important and the community relocated to Lunel-Viel which better served a north–south transit pattern, but the bridge continued in use until the late Middle Ages.