The Pontchartrain Expressway is a parallel six-lane section of Interstate 10 (I-10) and U.S. Route 90 Business (US 90 Bus.)

At the vicinity of West End Boulevard/Florida Avenue exit, the expressway turns to the southeast along the right-of-way for the former New Basin Canal which had been filled in between 1937 and 1947.

The expressway continues southeast along the upriver side of the CBD as an elevated highway that leads to the Crescent City Connection.

The Business U.S. 90 portion of the expressway was expanded in the mid 1980s to accommodate the second span of the Crescent City Connection which opened in 1988.

A new pumping station was completed adjacent to the expressway in 2004 to keep this area dry and allow the interstate to remain open in the event of an evacuation.

In the aftermath of Hurricane Katrina, this pumping station was overwhelmed and the railroad underpass and the entire I-610/West End Boulevard interchange was extensively flooded.