Warhol and Gerard Malanga began shooting in March 1965 in Sedgwick's posh New York City apartment.
The first reel depicts an out-of-focus Sedgwick waking up, ordering coffee and orange juice, smoking cigarettes and marijuana, exercising, taking pills and putting on makeup in silence.
[2] The second reel, which is in focus, shows Sedgwick lying on her bed and talking to her friend, Chuck Wein, who remains off-camera.
The rest of the film continues with Edie waking up Wein, the two discussing dreams (Wein alludes to his containing miles of people dressed like The Kingston Trio repeatedly playing "What Have They Done to the Rain"), Sedgwick talking on the telephone, during which Wein plays an album by The Shirelles, Sedgwick smoking an indistinguishable substance from a pipe, repeatedly applying lipstick, trying on different outfits, including a real leopard-skin coat (Wein describes the coat as "ugly," with buttons that look like "two-way radios"), casual conversation between the two including social situations and various friends, and vaguely describing how she spent her entire inheritance in six months.
In June 1965, Poor Little Rich Girl premiered at the Film-makers' Cooperative Cinematheque on a double bill with another Warhol film, Vinyl.