Established in 1958 by Bishop Joseph Oliver Bowers of the Society of the Divine Word (SVD), the school was originally founded as a seminary for boys aspiring to become priests.

The student body comprises approximately 2,100 boys, who are colloquially referred to as "Pojomma," while alumni are known as "Pojoba," with the response "Daasebre" serving as a cultural identifier among them.

The school aims to provide academic instruction alongside moral and disciplinary guidance, preparing students for both educational and personal development by the time they complete their studies.

During this visit, he held discussions with Nana Frempong Moposo II, the local chief, which facilitated the acquisition of land at Effiduase, Koforidua, for a Roman Catholic Church mission.

In early 1955, Bishop Bowers initiated plans to establish a junior seminary on the acquired land for the Diocese of Accra.

Jude SVD, Dr. Balduricus, and Dr. Lucian Orians overseeing the building of a classroom block and a combined residence and administrative facility.

In early 1957, Dr. Damian Brockmann, SVD, constructed the first science block, later replaced by a dormitory known as Elsbend House, named after the first headmaster.

The teaching staff included three SVD priests appointed by the Bishop and one Ghanaian lay teacher, Mr. Paul Ohene-Boakye, who assisted in the students' academic, moral, and religious education.

Maurice Lesage, SVD, then headmaster of St. Thomas Aquinas Senior High School in Accra, serving as the guest speaker.

examinations and was awarded a scholarship to study philosophy and theology at the Diocesan Seminary in Regensburg, Germany, departing on August 7, 1961.

The new name honored Pope John XXIII, who had convened the Second Vatican Council, while preserving the identity and mission of the original institution.

Dr. Charles G. Palmer-Buckle became the first bishop of the new diocese, which assumed responsibility for managing the school within the Ecclesiastical Province of Accra.

Since its establishment, approximately 8,000 students have graduated, with over 100 alumni ordained as Catholic priests, including Archbishop Charles G. Palmer-Buckle The school uniform, nicknamed "the Reflector," consists of a yellow shirt paired with blue shorts or trousers.

The yellow shirt is typically worn with shorts, while only Form 3 and final-year students are permitted to wear trousers.

Pope John Senior High School maintains a strong Roman Catholic culture, which influences many aspects of its operations and activities.

Pope John Senior High School and Minor Seminary is equipped with modern facilities, including a science laboratory, an ICT center, a library, a multipurpose athletic field, and basketball and volleyball courts, among others.

Pope John Senior High School and Minor Seminary has a chaplaincy, led by a chaplain appointed by the Archbishop of Accra.

The chaplaincy is responsible for organizing events like the annual St. Thomas Aquinas Day celebrations and the Kwahu-Tefo pilgrimage in the Eastern Region.

It brings together all Catholic students within the Eastern Region to honor their patron saint, St. Thomas Aquinas and discuss matters affecting them.

In 2012, the school placed 9th on the WASSCE order of merit (Education in Koforidua) and POJOSS has emerged victorious in many inter-school academic competitions.

Students of Pope John Senior High School and Minor Seminary are involved in Extracurricular activities through their membership in clubs and societies.

[18] The Pope John community has through the decades maintained a very cordial relationship with society, especially with the Roman Catholic Church, the town of Effiduase in Koforidua and sister schools across Ghana.

POJOROSA is the acronym representing the alliance between Pope John Senior High School and Minor Seminary, and St.

The school's boys' choir has performed at many Catholic events including the burial mass of their founder, Joseph Bowers.

In 2012 under the Community Impact Program, KNUST donated books to the school's library and supervised the renovation of its science lab.