Port Clarence is a census-designated place (CDP) in the Nome Census Area of Alaska.

Missionary Sheldon Jackson's greatest success with his Teller Reindeer Station at Port Clarence, figured in the Overland Relief Expedition in 1897 to save marooned whalers near Point Barrow.

[4] From 1961 to 2010 Port Clarence was a LORAN-C station administered by the United States Coast Guard.

[7] The Coast Guard commissioned a 1,350-foot (411.48-metre) tall Loran-C tower at the station in 1961, and it was the tallest structure in Alaska until its demolition in 2010.

The census enumerators included 11 small native villages of Anelo, Chainruk, Kachegaret, Kalulegeet, Kaveazruk, Kovogzruk, Metukatoak, Nuk, Perebluk, Shinnapago & Toakzruk.

Port Clarence would not be separately reported again on the census until 1980, when it was made a census-designated place (CDP).