Port Jefferson is a village in Salem Township, Shelby County, Ohio, United States.

Port Jefferson had its start around the time the Miami and Erie Canal was extended to that point.

There were 158 housing units at an average density of 929.4 per square mile (358.8/km2).

23.9% of all households were made up of individuals, and 7% had someone living alone who was 65 years of age or older.

There were 128 housing units at an average density of 831.3 per square mile (321.0/km2).

22.1% of all households were made up of individuals, and 6.6% had someone living alone who was 65 years of age or older.