The expressway is grade-separated at the North-South Motorway, Hanson Road and Eastern Parade interchanges.

Instead, an overpass was constructed with a loop through the Barker Inlet wetlands to provide a non-stop interchange.

[8] During 2018, 2019 and 2020, construction workers were putting up new elements on the expressway, as part of the Northern Connector project of the North–South Motorway.

[9][10] The bridge over the Port River includes a shared path on the southern side of the road.

[11] At the time of designing Stage 1 of the Expressway, the developers did not imagine that there would be much requirement for people to cycle along it, as Mawson Lakes had not been developed for housing yet, so the Port River Expressway was seen as only connecting industries to other industries.