Portrait of Amelia Opie is a 1798 portrait painting by the British artist John Opie depicting his wife Amelia Opie, a noted writer and abolitionist.

[2] The Cornish-born John Opie was a noted portraitist of the late Georgian era.

After his death in 1807 Amelia became a quaker known for her role in good causes.

Today the painting is in the collection of the National Portrait Gallery in London, having been acquired in 1887.

[3] It has been describe as "one the finest portraits of the era, rivalling in expression Reynolds' Sarah Siddons as the Tragic Muse".