Portrait of a Man is a c. 1478 painting by the Italian Renaissance painter Domenico Ghirlandaio (1449–1494) executed in tempera on wood.

The painting was cleaned and renovated, revealing the bright green background underneath a layer of oxidised pigment.

[1] In 15th-century Italy, the stylistic development of individual portrait-painting had awoken with new vigor after a thousand years of silence.

The last period in the history was in the antiquity, when the Romans were known for their prolific depiction of individual traits of peoples.

Originally attributed to Ghirlandaio, it was re-attributed to his brother-in-law and artistic follower Sebastiano Mainardi and sold in 1924.