Progression in the game spans across ten chapters, each marked by milestones in which players must perform more complex actions such as creating and selling more difficult potions to customers.

"[8] Jordan Devore of Destructoid described the mechanics as "easy enough to grasp", whilst noting the game features "depth", with "operating (the) shop in a sustainable way" amounting to a "satisfying gameplay loop".

[9] Describing the mechanics as "the best crafting system ever concocted", Rachel Watts of Rock Paper Shotgun praised the gameplay as "tactile but never difficult, and takes a wonderful finesse to master...that really captures the art of potion brewing.

"[8] Describing the game as "calm to play" and "beautifully presented", Robert Purchese of Eurogamer wrote "there's a soft parchmenty feel to everything and a sense of humour running through it.

"[12] Describing the game as "tactile", Rachel Watts of Rock Paper Shotgun praised the game's sound design, writing "(a) lovely set of details go into the way that everything sounds: the bubbling of the brew as you heat it up, the crunch of a root as you crush it into powder, and the gentle clanking of the mortar and pestle.

"[10] Potion Craft received several 'honorable mention' nominations for awards at the 2023 Independent Games Festival, including for 'Excellence in Design' and 'Excellence in Visual Arts'.