It opened in 1881, and operated until its acquisition by National City Corp. in 1993, as a member bank of Ohio Bancorp.

The bank was successful and the directors soon purchased property at Broadway and Fourth streets where they built a two-story brick and stone building.

The original building was taken over by the East Liverpool Potteries Company while the bank built and occupied their new offices.

The Potters National Bank operated within Home Savings and Loan Company of Youngstown until 2002.

This article about a property in Columbiana County, Ohio on the National Register of Historic Places is a stub.