It has produced animated content for educational companies including TED-Ed, Brain Chase, Compass Learning, Ignite!
Report Animated Archives" and "Jalen Rose Story Time" for ESPN's Grantland, and episodes of Kevin Smith's Spoilers series for SModcast and Hulu.
Powerhouse has produced animated advertising content for brands such as Old Spice, IAMS, Disney Parks, Disneyland, Metlife, Coca-Cola, Oreo, Mountain Dew, Ruffles, GoDaddy.com and many others.
In 2015, they worked with Weiden+Kennedy to animate a segment for a Weight Watchers ad called "All You Can Eat" that aired during Super Bowl XLIX.
Powerhouse has produced animated music videos for Lizzo, The Pains of Being Pure at Heart, Wale ft. French Montana, A Sound of Thunder and Lonestar.
In 2015, the company wrote, created, designed and voiced a short series for AwesomenessTV/DreamWorksTV called Advice Times with Grandpa Theo that can be seen on DreamWorksTV's YouTube page.
[7] Powerhouse worked on a Greek mythology–based anime-influenced animation series titled Blood of Zeus, released on Netflix in March 2019.
[10] October 5, 2021: Powerhouse Animation worked with Sega to release a launch trailer for Super Monkey Ball: Banana Mania.