It connects Poznań with Inowrocław, Toruń, and Olsztyn, then continues to the Polish-Russian border at Skandawa, Kaliningrad Oblast.

The line between Korsze and Żeleznodorożnyj became single track from 1 January 1945.

Electrification took place in six stages between 1976 and 1990: On 3 October 2016 PKP PLK signed a contract with ZUE for the modernisation of part of Line 353 on the section Ostrowite - Biskupiec Pomorski and Biskupiec Pomorski - Jamielnik within the project "Work on Line 353 on the section Jabłonowo Pom.

[1] The line sees trains of various categories (EuroCity, Express InterCity, Intercity, TLK and regional services).

Media related to Railway line 353 (Poland) at Wikimedia Commons