Pozuzo was isolated and difficult to access until 1976 when a vehicle road was completed linking the village with the town of Oxapampa, 80 kilometres (50 miles) north.

Smyth described the mule trail leading eastward from the Andes highlands to Pozuzo as narrow and dangerous.

[3] In the 1850s, Peruvian President Ramón Castilla proposed building a railroad from the capital city of Lima, across the Andes Mountains, and onward to the navigable rivers of the Amazon Basin.

[2] Schütz traveled to Germany in 1856 to recruit settlers and assembled a group of 302 persons, about 200 from the Tyrol and 100 from Moselle and Prussia.

The group departed Antwerp on the sailing ship Norton on 26 March 1857 and arrived in the port of Callao, Peru, on 8 August 1857.

The colonists undertook a difficult journey on foot and mule to reach Pozuzo, starting from the port of Huacho, reaching an elevation of more than 4,700 metres (15,400 ft) crossing the Andes, to Cerro de Pasco, onward to Acobamba (Ambo), and, constructing the road enroute, to Pozuzo.

The annual Pozuzofest attracts hundreds of visitors, some from Peru's capital Lima, 12 hours' drive away, and some from the Austrian Tirol and southern Germany.

[9] Pozuzo has an Af (tropical with adequate precipitation throughout the year) climate under the Köppen Classification system.