The station is located at a railway junction where the line from Kertapati split, with one goes to Lubuklinggau and the other one to Tanjung Karang.

Prabumulih Station was opened in 1915 along with the 78 km Prabumulih–Kertapati railway.

A new 73 km railway line connecting the station to Muara Enim was opened in 1917.

To the southeast of the station there is a rail service vehicles depot.

Media related to Prabumulih Station at Wikimedia Commons This Indonesian railroad station-related article is a stub.