Prachantakham (Thai: ประจันตคาม, pronounced [prā.t͡ɕān.tā.kʰāːm]) is a district (amphoe) of Prachinburi province, eastern Thailand.

Neighboring districts are (from the east clockwise): Na Di, Kabin Buri, Si Maha Phot, Mueang Prachinburi of Prachinburi Province; Pak Phli of Nakhon Nayok province; Pak Chong and Wang Nam Khiao of Nakhon Ratchasima province.

The Sankamphaeng Range mountains is in the northern section of this district.

The district is divided into nine sub-districts (tambons), which are further subdivided into 106 villages (mubans).

This Prachinburi Province location article is a stub.