The orchestra gives concerts in several venues in Prague, including the Dvořák Hall of the Rudolfinum, the Church of St. Simon and Jude, the Švanda Theatre in Smíchov and the Salon Philharmonia.

Jiří Bělohlávek founded the orchestra in 1993, after his resignation as chief conductor of the Czech Philharmonic the previous year.

The Czech Ministry of Defence had offered funding for training 40 young musicians to act as their own music ensemble, to replace the Prague Symphony Orchestra in that capacity.

In October 2014, the orchestra announced the appointment of Emmanuel Villaume as its fourth chief conductor, effective with the 2015–2016 season, with an initial contract of 3 years.

[3] The orchestra has made recordings for a number of labels, including Supraphon,[4][5] Deutsche Grammophon, Warner Classics, EMI, Harmonia Mundi,[6] and Pentatone.