Prairie Home is a city, in Cooper County, Missouri, United States.

The Prairie Home Conservation Area is two miles south along Schaaf Creek.

[6][7] According to the United States Census Bureau, the city has a total area of 0.39 square miles (1.01 km2), all land.

The racial makeup of the city was 98.9% White, 0.4% African American, 0.4% Asian, and 0.4% from two or more races.

As of the census[3] of 2000,[needs update] there were 220 people, 104 households, and 61 families living in the city.

The racial makeup of the city was 95.91% White, 0.45% Native American, and 3.64% from two or more races.

About 3.4% of families and 6.0% of the population were below the poverty line, including 3.1% of those under the age of eighteen and 16.7% of those 65 or over.