[7][9] In 2008, Prashanth Prakash along with Subrata Mitra founded the Indian arm of the US venture capital firm Accel.
[12][13] As a partner at Accel, Prashanth Prakash has played a vital role in shaping up renowned Indian startups such as Flipkart, Ola, Freshworks, Bookmyshow, Swiggy & Bounce amongst many others.
[17][18] In October 2024, Prashanth Prakash became the joint owner of the Bengaluru franchise team in the second season of the Global e-Cricket Premier League (GEPL).
[25] In 2021, Prashanth Prakash, in collaboration with several venture capitalists, established a 100-crore COVID fund[26] and created ACT Grants to encourage start-ups focused on developing products and services to tackle Pandemic related concerns.
[27] In August 2022, Prashanth Prakash partnered with The Indian Institute of Science to set up a geriatrics wing as part of IISc's upcoming Bagchi-Parthasarathy Hospital.