Prathersville is a village in Clay County, Missouri, United States.

A post office called Prathersville was established in 1876, and remained in operation until 1904.

[6] According to the United States Census Bureau, the village has a total area of 2.26 square miles (5.85 km2), all land.

35.7% of all households were made up of individuals, and 21.4% had someone living alone who was 65 years of age or older.

25.5% of all households were made up of individuals, and 17.0% had someone living alone who was 65 years of age or older.

There were no families and 4.0% of the population living below the poverty line, including no under eighteens and 5.1% of those over 64.