Prattsville is a hamlet and census-designated place (CDP) in the town of Prattsville, Greene County, New York, United States.

The CDP is bordered to the southwest by Schoharie Creek and to the southeast by its tributary, Batavia Kill.

The northwestern edge of the CDP follows the Delaware County line, and the far northern extent of the CDP borders Schoharie County.

New York State Route 23 is Prattsville's Main Street, leading northwest 39 miles (63 km) to Oneonta on the Susquehanna River and southeast 36 miles (58 km) to Catskill on the Hudson River.

According to the United States Census Bureau, the Prattsville CDP has a total area of 4.1 square miles (10.5 km2), all land.