The location was chosen because the creek could supply power to the cotton gin manufacturing equipment.

I-65 runs north to south east of downtown, with access from exits 179 and 181, both in the Elmore County portion of the city.

US 82 runs south with I-65 to downtown Montgomery, and northwest 89 mi (143 km) to Tuscaloosa.

As of the 2020 United States census, there were 37,781 people, 14,069 households, and 9,658 families residing in the city.

On February 17, 2008, Prattville was hit by an EF3 tornado which destroyed more than 45 homes and businesses and damaged over 700.

East Memorial Christian Academy was located in an unincorporated area of Autauga County, near Prattville, until it was closed down.

DirecTV and Dish Network provide direct broadcast satellite television including both local and national channels to area residents.

The 2014 event, now known as the Yokohama Tire LPGA Classic after its new sponsor, was scheduled for September 18–21.

Major highways that pass through the city include: Prattville also has a small airport about 3.5 miles from downtown.

[16] Known for the signature hill that turns into a steep curve, located on present-day 6th Street, Happy Hollow was the center of African American life in Prattville in the 1950s.

This marker was erected to honor the spirit of "equality" that resonated in Happy Hollow.

[17] Gabriel García Marquez mentions Prattville in his well-known work One Hundred Years of Solitude; Prattville is referred to as the original city of Jack Brown, the founder of the banana company.

[20] A popular ghost-story known as "The Black Lady," inspired by deaths caused by poor working conditions in the nearby factories of downtown Prattville, is a popular phenomenon described by most as a black, ghastly figure that goes across the nearby dam during the night hours of 1 am to 4 am and has been featured on the ghost hunting show, Deep South Paranormal.