[citation needed] She was selected for the lead role in 2010 Indian television series Balika Vadhu as an adult version of Anandi, replacing Avika Gor.

According to the actress, she was chosen via a talent hunt, surpassing the contestants Nivedita Tiwari from Lucknow and Ketaki Chitale from Mumbai.

[14] Banerjee had played vital roles in Hum Hain Na,[15] Sasural Simar Ka and Gulmohar Grand.

[17] Pratyusha was born in a Bengali family in Jamshedpur city of Jharkhand to Shankar and Soma Banerjee.

[23] After this in 2018 her boyfriend Rahul Raj Singh has filed an application before the Dindoshi sessions court in Mumbai, requesting to be discharged from the case.