PreQ1-III riboswitch

Most sequenced examples of preQ1-III riboswitches are obtained from uncultivated metagenome samples, but the few examples in cultivated organisms are present in strains that are known to or suspected to be Faecalibacterium prausnitzii, a species of Gram-positive Clostridia.

Known examples of preQ1-III riboswitches are found upstream of queT genes, which are expected to encode transporters of a queuosine derivative.

The other two known classes of preQ1 riboswitches are also commonly found upstream of queT genes.

The atomic-resolution structure of a preQ1-III riboswitch has been solved by X-ray crystallography.

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Consensus secondary structure of PreQ 1 -III riboswitches, based on earlier data than a previously published depiction. [ 1 ] The structural significance of the pairing interaction labeled "pseudoknot or alternate stem" is currently unknown. The P1 stem is unusually rich in A and U nucleotides, but is supported by experimental data.