In its inaugural season, 1932–33, the club competed in Liverpool's Business Houses League [2] winning the League and Challenge Cup titles without dropping a point in the former.
[4] Among the new division's eighteen founder members, Prescot BI finished the 1978-79 season 8th; in the following three seasons, they were placed 4th, 6th and 13th, before leaving to become founder members of the North West Counties League in 1982.
The club thereafter competed only locally, in the St Helens Combination, where they remained until at least the 1998–99 season.
[5] They entered the FA Cup twice, in 1948-49 and 1949–50, losing in the extra-preliminary round on both occasions, to St Helens Town and Haydock C&B Recreation respectively.
In the FA Vase, they reached the first round proper three times, in the 1976–77, 1980–81 and 1981–82 seasons.