[1][2] On 16 December 2019, after his victory in the second round and before his inauguration, he announced his cabinet consisting of leaders of National, Colorado, Cabildo Abierto and Independent parties, members of the Multicolor Coalition.

[8] Lacalle condemned the Russian invasion of Ukraine and Hamas as terrorism during the Israel–Hamas war, as well as accused Nicolás Maduro, Daniel Ortega and Miguel Díaz-Canel of leading dictatorial governments in their respective countries.

[15] Facing the 2019 runoff election, Lacalle Pou led the Coalición Multicolor, an electoral alliance made up of center-right parties.

The Electoral Court of Uruguay would publish the official results by Friday, 29 November 2019, as observed votes were still to be counted, totaling more than the difference between the two candidates, thus being too close to call.

[22] On 2 December 2019 president-elect Luis Lacalle Pou met up with outgoing president Tabaré Vázquez in the Executive Tower to begin the transition process.

After making the Constitutional Oath after the General Assembly, they paraded from Libertador Avenue travelling in a convertible 1937 Ford V8 that belonged to his great-grandfather Luis Alberto de Herrera.

The inauguration tour in Montevideo ended at the Plaza Independencia, where Lacalle Pou received the presidential sash from the outgoing president Tabaré Vázquez.

Due to that, the measures taken by the government to deal with the health emergency delayed the presentation of the project, which finally reached the General Assembly on 23 April 2020.

[32] In the first weeks of started this administration, the Uruguayan authorities had to deal with the arrival of the COVID-19 pandemic, that forced the declaration of national health emergency and the adoption of several exceptional measures.

[35][36] Due to the resignation of Ernesto Talvi as Minister of Foreign Affairs in early July,[37][38] Lacalle Pou appointed the former Ambassador of Uruguay to Argentina and Spain, Francisco Bustillo, as head of the ministry.

[41] On 27 June 2021 the fifth change in Lacalle Pou's cabinet has occurred with the replacement of Carlos María Uriarte with Fernando Mattos as the new minister of Livestock, Agriculture and Fisheries, until then president of the National Institute of Meat, being both members of Colorado party.

[55] During a parliamentary discussion of the Budget Law draft, the minister of Education and Culture Pablo da Silveira stood up for this measure arguing that these centers were a "kind of independent republic" and that their politics "did not coincide" with what the Ministry was intending to do.

[56] This change was condemned by the Broad Front legislators, among them member of parliament Gabriel Otero twitted saying that "67 cities were left without MEC Centers, they destroyed them without thinking about the people, without culture there is no future".

[59] The Air Force put its fleet of Cessna A-37 Dragonfly into operation to conduct "reconnaissance, patrol, and surveillance" of the Northeast, while the Navy deployed its personnel and equipment in border lakes and rivers.

[63] The aircraft arrived in Uruguay on December 19, Defense Minister Javier García stated that "a process of modernization of essential equipment begins.

[65] Chaired by President Lacalle Pou, it is an advisory and consultative body that works on the drafting of a decree with the defense guidelines for the entire term.

It established general guidelines to deploy and develop telehealth as a way to improve the efficiency and quality of medical services, as well as to expand their coverage by using information and communications technologies.

According to that Law, the development of telehealth must be performed under the following principles: universality, guaranteed access of the entire population to health, equity by allowing the medical attention in remote locations or those without resources, quality of services both towards the patient and the personnel training, efficiency by optimizing the use of resources, decentralization of the National Integrated Health System, complementarity but without replacing direct treatment of the patient, and confidentiality of the medical-patient relationship as well as protecting the privacy during the remote exchange of medical information.

[84] To address this legal problem, the Broad Front representative Cristina Lustemberg promoted a reform bill to modify article 7 so that in medical procedures through telehealth the principle of progressive autonomy of minors' and disabled persons' will is observed, in order to fix the regression of rights.

[89] Lacalle's government ordered the withdrawal of Uruguay from the Union of South American Nations (UNASUR), arguing that it occurred because "it is an organization that became an ideological political alliance contrary to the country's objectives of linking.

There they had a typical Uruguayan asado and discussed bilateral, regional and Mercosur-related issues, such as business opportunities with the European Union and the Paraná-Paraguay and Rio Uruguay waterway.

"[104] On February 17, Lacalle received Paraguayan President Mario Abdo Benítez at the presidential residence in Punta del Este on an official visit.

[107][108] In May 2021, during the Israel–Palestine crisis, the Uruguayan government expressed its "deep concern over the acts of violence" and encouraged Israelis and Palestinians to curb it and guarantee the safety of all sacred sites.

[109][110] In July 2021, the Lacalle Pou administration informed the member countries of the Southern Common Market (MERCOSUR) that Uruguay will begin bilateral trade negotiations outside the bloc.

[113] On September 7, after meeting with the leaders of all political parties with parliamentary representation, Lacalle Pou announced at a press conference that formal negotiations had begun to carry out a pre-feasibility study for the signing of a treaty on free trade with the People's Republic of China.

[117][118] On 23 February 2022, Uruguay's Ministry of Foreign Relations issued a statement condemning the use of force and urging all parties involved to take the necessary measures to reduce tensions and achieve a political agreement.

The Uruguayan government expressed "concern" about the situation with the recognition of the separatist republics of Donetsk and Luhansk as sovereign states by Russia and the displacement of military troops, in violation of the principles of the Charter of the United Nations.

[119] After the invasion President Luis Lacalle Pou condemned Russia's "actions contrary to international law", and declared that Uruguay "is a country that is always committed to peace", for which he encouraged the return of negotiations for a "civilised resolution" of the conflict.

[124][125] In turn, the UK government announced that it will continue to invest in education and training opportunities for the Uruguayan Armed Forces, and that both countries will remain associated within the framework of the UN Action for Peacekeeping Initiative.

[126] According to a survey by Equipo Consultores, released on March 31, 2020, in Lacalle's first month as president, 65% of the Uruguayan population approved of his administration, while 20% disapproved of it and another 15% did not have an "intermediate opinion" or did not respond.