The President's House of Keene State College, formerly the Catherine Fiske Seminary For Young Ladies, is a historic house at 251 Main Street in Keene, New Hampshire.

Its exterior is Italianate in style, with a symmetrical five-bay facade adorned with elaborate window lintels and a cornice with paired brackets.

An Italianate porch shelters the main entrance, supported by clustered square columns.

The house served as a girls' school from 1824 to 1844 under the oversight of Catherine Fiske.

Its associated carriage barn, used for vocational automotive training, burned in 1925, and its basement hole was converted into a sunken garden.