Preston is a town in Trempealeau County, Wisconsin, United States.

According to the United States Census Bureau, the town has a total area of 59.2 square miles (153.2 km2), of which, 59.2 square miles (153.2 km2) of it is land and 0.02% is water.

As of the census[2] of 2000, there were 951 people, 333 households, and 263 families residing in the town.

There were 372 housing units at an average density of 6.3 per square mile (2.4/km2).

17.4% of all households were made up of individuals, and 9.9% had someone living alone who was 65 years of age or older.