Preston Blake Guilmet (/ˈɡɪlmɛt/ GIL-met;[1] born July 27, 1987) is an American former professional baseball pitcher.

He played in Major League Baseball (MLB) for the Cleveland Indians, Baltimore Orioles, Tampa Bay Rays, Milwaukee Brewers, St. Louis Cardinals, Toronto Blue Jays, and Miami Marlins.

[3] He made his professional debut with the Low-A Mahoning Valley Scrappers, pitching to a 6–6 record and 4.09 ERA in 15 appearances with the team.

In 2011, he played for the High-A Kinston Indians, posting a 2.16 ERA with 35 saves and 60 strikeouts in 58.1 innings of work.

[4] He made his major league debut on July 10 against the Toronto Blue Jays, and was optioned back to Columbus the next day.

[7] After pitching six scoreless innings in his first five games with the Orioles,[8] he picked up his only decision with the ballclub in a 3–1 loss to the Houston Astros at Minute Maid Park on May 29.

[7] He was designated for assignment on September 27 when the Orioles needed to make room on its 40-man roster for Alexi Casilla, who had been promoted from the Tides.

During the 2015 season, Guilmet played for four different Triple-A organizations, Buffalo, Durham, Oklahoma City and Colorado Springs.

On December 11, 2015, Guilmet signed a minor league contract with the Detroit Tigers organization, and was invited to spring training as a non-roster invitee.

[19] He spent the season with the Triple-A Toledo Mud Hens, pitching to a 3–3 record and 2.77 ERA in 65 appearances for the team.

[20] On November 21, 2016, Guilmet signed a one-year, $600,000 contract with the Tokyo Yakult Swallows of Nippon Professional Baseball (NPB).

On January 5, 2018, the St. Louis Cardinals signed Guilmet to a minor league contract that included an invitation to Spring Training.

St. Louis purchased his contract from Memphis on June 5, 2018, and he made his Cardinals debut the same night at Busch Stadium.

[25] On June 9, 2018, the Toronto Blue Jays claimed Guilmet off waivers, and designated pitcher Deck McGuire for assignment.

[32] He was assigned to the Triple-A Jacksonville Jumbo Shrimp to begin the 2021 season, and logged a 4.08 ERA in 9 appearances with the team.