The estate was sold to the Sisters of the Divine Compassion in 1927 and they established The House of the Holy Family as a residence and a school for girls.

The school's motto is Virtus Mille Scuta, a Latin phrase meaning "Virtue is a thousand shields" .

The school shield comprises the coat of arms of Monsignor Thomas Preston and the seal of the Sisters of the Divine Compassion.

[citation needed] The school maintains excellent percentiles in the New York State Regents exams – particularly in the fields of English, social studies, and the humanities.

The school serves the Roman Catholic Archdiocese of New York, but is not directly affiliated with a particular parish.

The building served as the residence for the school's sisters until the summer of 2004, when their apartments were converted to accommodate a growing student body.