Pretzsch (German pronunciation: [ˈpʁɛtʃ] ⓘ) is a small town and a former municipality in Wittenberg district in Saxony-Anhalt, Germany.

Pretzsch lies in the middle of the Elbauen (natural polders along the Elbe), on the river's west bank which is on the northwest edge of the Düben Heath Nature Park.

In the 17th century, August II the Strong's wife Christiane Eberhardine of Brandenburg-Bayreuth lived there and is buried in the town church.

As of 1952, when East Germany abolished the Land system, Pretzsch was in the Halle region, until 1990 when the Land system was revived in the former East Germany at German Reunification.

The SS Einsatzgruppen, the perpetrators of the initial phase of the Holocaust that preceded the invention of the more efficient Nazi death camp system, were first assembled at a police academy in Pretzsch in the spring of 1941.