In this episode, Lois discovers that Chris' school has removed the sex education program due to budget cuts and decides to bring the class back by becoming the teacher.
The episode featured guest performances by Drew Barrymore, Mindy Cohn, Gary Cole, Taylor Cole, Lauren Conrad, David Cross, Margaret Easley, Lauren Hooser, Kim Parks, Kevin Michael Richardson, André Sogliuzzo and Crawford Wilson, along with several recurring guest voice actors for the series.
After Mayor West breaks the window of an adult video store with a "cat launcher" while chasing a pizza delivery guy due to West receiving the wrong pizza toppings, Chris and his friends steal some videos from the store and watch one of the pornographic films with Stewie, who is very confused at the plot of the film making little sense.
Soon after the first sex-ed class, parental protests arise as Lois taught kids about safe ways to perform premarital sex, instead of abstinence.
She is replaced by reverend Jerry Kirkwood, who promotes both premarital and marital abstinence, explaining fictional consequences of intercourse with various questionable examples.
Peter, truly believing the anti-sex propaganda Meg brings home, starts wearing a chastity belt and refuses to have sex with Lois.
In the scene involving Stewie entering Herbert's house, a picture of Chris with the body of a model was in the animatic, but not shown on TV.
In addition to the regular cast, actors Drew Barrymore, Mindy Cohn, Gary Cole, Taylor Cole, Lauren Conrad, David Cross, Margaret Easley, Lauren Hooser, Kim Parks, Kevin Michael Richardson, André Sogliuzzo and Crawford Wilson guest star in the episode.
Recurring guest voices include Lori Alan, Alex Breckenridge, Steve Callaghan, Chris Cox, Ralph Garman, Danny Smith, Alec Sulkin, John Viener, and Adam West, who has a role of an exaggerated version of himself.
", a cut-a-way scene then begins of a sports car driving along the road with music playing in the background, this is a reference to Knight Rider.
[5] When Lois catches Chris and his friends watching a pornographic film, she tells them that without sex education, they can easily become sexually confused.
When Lois teaches a sex education class, Peter uses a bust of William Shakespeare and a Rainbow Brite doll to demonstrate sexual intercourse.
[7] In his review of Family Guy, volume 5, Francis Rizzo III of DVD Talk called the episode "a smart jab at the conservative Christian approach to sex education", and stated that "the effect it has on Meg, as well as Peter, is great".