The station building faces toward the town centre and is located to the west of the railway.

To the west Hochriesstraße runs from the Bahnhofsplatz (station forecourt), branching off Seestraße.

East of the station area is Hallwangerstraße and on the other side of the street are the tracks of the Chiemsee Railway.

In the following years traffic to the station grew because of the construction of the new Herrenchiemsee palace, which was completed in 1885.

Deutsche Bundesbahn stationed a locomotive of class 323 in Prien for local freight traffic after the Second World War.

However, they are not accessible for the disabled and only partially fitted with digital train destination indicators.

The station's long-distance services are InterCity and EuroCity trains between Munich and Austria.

One pair of trains of EC line 32 runs between Münster (Westfalen) or Dortmund and Klagenfurt and is called the Wörthersee.

Regional traffic stopping at the station includes an hourly Regional-Express (RE5) service between Munich and Salzburg.

These consist of double-deck push–pull trains propelled by class 111 locomotives operated by Bayerische Regiobahn.