Located south of the city centre, it soon proved to be too small after the opening of the line to Salzburg in 1860 and the Austrian Brenner Railway in 1867.

After only 18 years of usage, the old station building was sold to the City of Rosenheim and serves as its town hall (Rathaus) up to today.

The new station, a Neo-Renaissance building, was large enough to cope with the additional traffic on the newly opened line to Mühldorf from 1 May 1876.

It was nevertheless rebuilt and enlarged several times during the following decades, including an extended freight yards and a locomotive depot (Bahnbetriebswerk).

Every hour trains arrive from Salzburg, Munich, Innsbruck, Kreuzstraße/Holzkirchen and Mühldorf am Inn roughly at the same time and depart a few minutes later.