It was established because it was near to the major towns of Meissen and Großenhain, which both received direct rail connections about two decades later.

After the opening of the line, a shed used during its construction was used as a freight receiving facility and waggon depot.

The station building itself consisted of a small wooden platform hall for passengers, a barn-like freight shed, an open hall for the reloading the freight onto waggons and a blacksmith for the repair of waggons.

[3] Priestewitz benefited from the railway, so the town quickly experienced an economic boom.

It replaced the first station buildings from 1839, which no longer coped with the increasing volume of traffic.

The Verkehrsverbund Oberelbe (Upper Elbe Transport Association, VVO) invested approximately €1.3 million in a new interchange in front of the station in 2005.

A parking lot in front of the railway station caters for commuter traffic.