Cardiovascular symptoms: mass effect compromising myocardial function or blood flow, causing arrhythmias, obstruction of heart valves leading to regurgitation, or pericardial effusion with or without tamponade.

Primary symptoms include breathlessness, chest pain, presyncope, and syncope.

[5] Symptoms caused by primary cardiac tumors are usually dependent on size and location.

The mass size can obstruct blood flow or interfere with cardiac valve function and produce symptoms of heart failure.

Tumors that invade adjacent lung tissue may cause pulmonary symptoms that mimic bronchogenic carcinoma.

Tumors with the highest anatomic risk for embolization are located in the left atrium or aortic valve.

[7] Systemic symptoms[8] Primary cardiac tumors may secrete factors including interleukin-6 and endothelin.

Systemic symptoms including fever, fatigue, arthralgia, anemia, elevated white blood cell count, thrombocytosis, thrombocytopenia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate.

Prompt resection is indicated for myxomas due to the risk of embolization or cardiovascular complications.

Close observation has also been suggested for cardiac tumors that are small (<1 cm) and non-mobile.