The prime minister of Timor-Leste, officially the Prime Minister of the Democratic Republic of Timor Leste (Portuguese: Primeiro-Ministro da República Democrática de Timor-Leste; Tetum: Primeiru-Ministru Republika Demokratika Timor-Leste; formerly East Timor), is the head of government in Timor-Leste.

The president appoints the prime minister, after parliamentary elections and have listened to all parties represented in the National Parliament, who is usually the leader of the majority party or majority coalition.

The prime minister is ex officio a member of the Council of State, chairs the cabinet and oversees the activities of the government.

The Constitution of Timor-Leste provides, in sections 104 and 105, for the appointment of officials referred to in its English language version as "Deputy Ministers".

In other English language publications, those officials are commonly referred to as "Vice Ministers", even though the word "Vice", in context, arguably has a different meaning in English from the word "Deputy".