He came to Venezuela in 1948 and became one of the foremost teachers of composition in the country at the Conservatorio Nacional de Música Juan José Landaeta.
His students include composer Alfredo del Monaco, winner of the Tomás Luis de Victoria Ibero-American Prize, and the internationally active conductors Maria Guinand and Carmen Helena Téllez.
He also developed in Venezuela an intense activity as conductor, a career that had begun in Milan with a chamber orchestra that he himself had founded and which traveled through Italy and Germany.
In 1969, on initiative of Rhazés Hernández López, performed the opera Virginia by José Ángel Montero.
Hernández López commissioned to Primo Casale the revision of the original manuscripts and its reorquestación, since some parts had gone astray.