The characters and concept were created by actor Leonard Nimoy, who developed the idea for the series after visiting the SETI project.

The script of the debut issue of Primortals was credited to Kate Worley and Lawrence Watt-Evans with art by Scot Eaton and Mike Barreiro.

Eaton and Barreiro illustrated the comic for most of its run, while the book was most often scripted by Christopher Mills and later James Chambers.

The series showed how, in ancient times, aliens called the Majae removed various species from Earth and raised them to sentience.

An interactive CD-ROM was released by Big Entertainment in 1996, allowing the reader to see the beginning of the story from 4 different points of view.