[5] Susan Bay's film debut in a leading role occurred in the Jerry Lewis comedy The Big Mouth (1967).

[11] She played Admiral Rollman in Star Trek: Deep Space Nine's first and second season in the episodes "Past Prologue" (1993) and "Whispers" (1994).

In 2019, she began to appear in the CDC's Anti-Smoking Campaign "Tips from Former Smokers" discussing her late husband's battle with COPD.

[14] In 1979, Bay and other members of the Original Six, a group of women directors, created the Women's Steering Committee of the Directors Guild of America, to protest against gender discrimination in Hollywood and support female employment on film and television sets at the directing level.

[citation needed] In 2007, Bay directed the American premiere of Shakespeare's Will, a solo play by Vern Thiessen that featured Jeanmarie Simpson as Anne Hathaway.

[22] In 1999, Bay and Nimoy made a $100,000 donation to the Museum of Contemporary Art, Los Angeles (MOCA) so it could purchase The Ballad of Sexual Dependency by Nan Goldin.

[29] She was photographed for Nimoy's Shekhina, a book of monochrome nude photography of women representing Shekhinah, the presence of God in Judaism.