Antonio, Count of Lecce was the fourth son of King Francis I of the Two Sicilies and his second wife Maria Isabella of Spain.

He was born on 23 September 1816 at Palermo, during the reign of his paternal grandfather, Ferdinand I of the Two Sicilies who gave him the title of Count of Lecce.

During the reign of his brother King Ferdinand II, Antonio quickly became known for his restless behavior.

[2] In 1837, Ferdinand II arranged his marriage to Louise Marie Thérèse d'Artois, his niece, a daughter of his half sister Caroline, Duchess of Berry.

He was clubbed to death on 12 January 1843 by the jealous husband of a married woman he had tried to seduce.